I-Nicotinamide Mononucleotide Powder Ezindabeni

I-Nicotinamide Mononucleotide (NMN) powder ibilokhu yenza amagagasi emphakathini wesayensi kanye nemibuthano yezempilo ngokufanayo. Le nhlanganisela ethembisayo, isandulela se-NAD+ (i-nicotinamide adenine dinucleotide), izuze ukunakwa okuphawulekayo kwezindawo zayo zokulwa nokuguga ezingase zibe khona kanye nezinzuzo zezempilo zizonke. Njengoba ucwaningo luqhubeka futhi nentshisekelo yomphakathi ikhula, i-nicotinamide mononucleotide powder isaqhubeka nokuba yindatshana ezindabeni. Ake sihlole intuthuko yakamuva ephathelene nalesi sengezo esithakazelisayo.

Izifundo Zakamuva Ezigqamisa Amandla e-NMN

Umphakathi wesayensi ubulokhu umatasatasa ngocwaningo olusha oluhlola amandla amakhulu e-NMN powder. Izifundo eziningana eziyisisekelo ziye zasikhanyisela ngokusebenza kwazo ezicini ezihlukahlukene zempilo nokuphila isikhathi eside.

Ucwaningo lwakamuva olushicilelwe ku-Journal of Molecular Biology luhlole umthelela we-NMN kumetabolism yamandla eselula. Abacwaningi bathole ukuthi ukwesekwa kwe-NMN kukhulisa kakhulu ukusebenza kwe-mitochondrial kumagundane asebekhulile, okungenzeka kubuyisele emuva ezinye izici zokwehla okuhlobene nobudala. Lokhu okutholakele kubangele isasasa ngendima ye-NMN ekukhuthazeni ukuguga okunempilo ezingeni lamaselula.

Olunye ucwaningo oluthakazelisayo, olufakwe ku-Nature Communications, luphenye imiphumela ye-NMN ekusebenzeni kwengqondo. Ithimba locwaningo lithole ukuthi abaphathi be-NMN bathuthukise inkumbulo nekhono lokufunda kumagundane amadala, liphakamisa izinhlelo zokusebenza ezingaba khona ekulweni nokwehla kwengqondo okuhlobene neminyaka. Le miphumela igqugquzele ukuhlola okwengeziwe ezicini ze-NMN ze-neuroprotective.

Ukwengeza, ukubuyekezwa okuphelele kwe-Frontiers in Cell and Developmental Biology kuhlole amandla e-NMN empilweni yenhliziyo nemithambo yegazi. Ababhali baqokomisa izifundo ezimbalwa ezibonisa ikhono le-NMN lokuthuthukisa ukusebenza kwenhliziyo, ukunciphisa ukuvuvukala, nokuthuthukisa ukugeleza kwegazi kumamodeli ezilwane. Nakuba izivivinyo zabantu zisesezigabeni zazo zokuqala, lokhu okutholakele kunikeza isisekelo esiqinile socwaningo olwengeziwe I-Nicotinamide Mononucleotide Powder izinzuzo zenhliziyo nemithambo yegazi.

I-NMN Ekukhanyeni: Lokho Okushiwo Ochwepheshe

Njengoba i-NMN powder iqhubeka nokuthola i-traction emibuthanweni yesayensi, ochwepheshe abavela emikhakheni ehlukahlukene baye balinganisa amandla ayo kanye nokuma kwamanje emhlabeni wezempilo nokuphila kahle.

UDkt. David Sinclair, isazi sezakhi zofuzo esaziwayo nomcwaningi wokuphila isikhathi eside e-Harvard Medical School, ube ngumgqugquzeli ozwakalayo wocwaningo lwe-NMN. Engxoxweni yakamuva nomagazini wezempilo ohamba phambili, uDkt. Sinclair uthe, "I-NMN imele indlela ethembisayo emzamweni wethu wokuqonda kanye nokukwazi ukunciphisa inqubo yokuguga. Nakuba sisesezigabeni zokuqala zocwaningo lwabantu, idatha ye-preclinical ikhuthaza ngendlela emangalisayo."

Isazi sokudla okunempilo kanye nombhali othengisa kakhulu uDkt. Rhonda Patrick naye uzwakalise ukuba nethemba ngamandla e-NMN. Ngesikhathi se-podcast yezempilo edumile, waphawula, "Ucwaningo oluzungeze i-NMN luyathakazelisa. Ikhono layo lokukhulisa amazinga e-NAD+ lingaba nemithelela efinyelela kude empilweni yeselula nempilo ende. Nokho, kubalulekile ukusondela kulokhu ngokuqiniseka ngokuqapha futhi ulinde izifundo eziningi zabantu."

UDkt. Nir Barzilai, umqondisi we-Institute for Aging Research e-Albert Einstein College of Medicine, wanikeza umbono olinganiselayo ochungechungeni lwakamuva lwesayensi. Waphawula, “Ngesikhathi I-Beta-Nicotinamide Mononucleotide (NMN) ikhombisa isithembiso, kufanele siqaphele ukuthi singasebenzisi ngokweqile amandla ayo. Sidinga izifundo eziqinile, zesikhathi eside kubantu ukuze siqonde ngempela imiphumela yako kanye nezinhlelo ezingase zisetshenziswe."

Amathrendi Esikhathi esizayo Kusengezo se-NMN

Njengoba ucwaningo lwe-NMN powder luqhubeka, izitayela eziningana ziyavela ezingase zimise ikusasa layo endaweni yezempilo kanye nokuphila kahle.

Amasu okudosa okomuntu siqu ayakhula. Ososayensi bahlola ukuthi izici ezifana neminyaka, izakhi zofuzo, nesimo sezempilo sisonke singaba nomthelela kanjani ekuphenduleni komuntu ekufakweni kwe-NMN. Lokhu kungaholela ezindleleni eziklanyelwe ukusetshenziswa kwe-NMN, kwandiswe izinzuzo zayo ezingaba khona kuyilapho kunciphisa noma yimiphi imiphumela emibi engaba khona.

Imithi yokwelapha eyinhlanganisela ingenye indawo yesithakazelo esikhulayo. Abacwaningi baphenya ukuthi i-NMN ingasebenzisana kanjani nezinye izinhlanganisela ezaziwa ukusekela impilo yamaselula nokuphila isikhathi eside. Isibonelo, ezinye izifundo zibheka imiphumela ehlanganisiwe ye-NMN ne-resveratrol, enye i-molecule ehambisana nezakhiwo zokulwa nokuguga.

Izindlela zokulethwa ezithuthukile nazo seziseduze. Ngenkathi I-Beta-Nicotinamide Mononucleotide (NMN) okwamanje iyindlela evamile yokwengeza, ososayensi bahlola izindlela ezintsha zokuthuthukisa i-bioavailability nokusebenza kwayo. Lokhu kuhlanganisa ukwakheka kwe-liposomal, amaphilisi okukhishwa kwesikhathi, kanye nezinhlelo zokusebenza ze-transdermal.

Ukwakheka kwezwe elilawulayo elizungeze i-NMN kungenzeka nakho kuguquke. Njengoba ucwaningo olwengeziwe luvela, iziphathimandla zezempilo emhlabeni wonke zingase zibuyekeze isimo sazo ku-NMN njengesengezo sokudla noma i-ejenti yokwelapha engaba khona. Lokhu kungaba nomthelela omkhulu ekutholakaleni kwayo nasekusetshenzisweni kwayo emazweni ahlukene.

Isiphetho

I-Nicotinamide Mononucleotide powder iyaqhubeka nokuthatha abacwaningi, ochwepheshe bezempilo, kanye nomphakathi ngokufanayo. Amandla ayo okuba nomthelela empilweni yamaselula, ukulwa nokwehla okuhlobene neminyaka yobudala, kanye nokukhuthaza inhlalakahle jikelele akubeke kwaqina ekukhanyeni kocwaningo lokulwa nokuguga. Nakuba indikimba yamanje yobufakazi iyathembisa, kubalulekile ukuxhumana nokwesekwa kwe-NMN ngokuqapha unolwazi.

Njengoba silindele izifundo ezibanzi zabantu, ikusasa le-NMN libukeka liqhakazile. Kusukela kumasu okudosa komuntu siqu kuye ezindleleni zokuletha ezintsha, inkambu ivuthwe ngamathuba. Ukuthi i-NMN izophila ngokuvumelana namandla ayo njengoshintsho lwegeyimu empilweni nokuphila isikhathi eside kusazobonakala, kodwa into eyodwa eqinisekile: izoqhubeka nokuba sematheni eminyakeni ezayo.

Kulabo abathanda ukufunda kabanzi mayelana I-Nicotinamide Mononucleotide Powder kanye nezicelo zayo ezingase zibe khona, kuhlale kungcono kakhulu ukuthintana nabasebenzi bezempilo futhi uhlale unolwazi mayelana nentuthuko yakamuva yocwaningo. Uma unemibuzo mayelana ne-NMN noma ezinye izithako zemithi yemvelo, sicela ungangabazi ukusithinta ku- information@sxrebecca.com.

Okubhekwayo

1. Yoshino, J., Baur, JA, & Imai, SI (2018). I-NAD+ intermediates: I-biology namandla okwelapha e-NMN ne-NR. I-cell metabolism, 27(3), 513-528.

2. Mills, KF, Yoshida, S., Stein, LR, Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, SI (2016). Ukuphathwa kwesikhathi eside kwe-nicotinamide mononucleotide kunciphisa ukwehla komzimba okuhlobene nobudala kumagundane. I-cell metabolism, 24(6), 795-806.

3. U-Hong, W., Mo, F., Zhang, Z., Huang, M., & Wei, X. (2020). I-Nicotinamide mononucleotide: I-molecule ethembisayo yokwelapha izifo ezihlukahlukene ngokukhomba i-NAD+ metabolism. Imingcele kuseli kanye nesayensi yentuthuko, 8, 246.

4. Kiss, T., Balasubramanian, P., Valcarcel-Ares, MN, Tarantini, S., Yabluchanskiy, A., Csipo, T., ... & Csiszar, A. (2019). Ukwelashwa kwe-Nicotinamide mononucleotide (NMN) kunciphisa ingcindezi ye-oxidative futhi kukhulule umthamo we-angiogenic kumaseli e-cerebromicrovascular endothelial asebekhulile: indlela engaba khona yokuvimbela ukukhubazeka kwengqondo kwemithambo. I-GeroScience, 41(5), 619-630.

5. Rajman, L., Chwalek, K., & Sinclair, DA (2018). Amandla okwelapha ama-molecule e-NAD-boosting: ubufakazi be-vivo. I-cell metabolism, 27(3), 529-547.