Other Name:Yohimbine HCL;Corynante Yohimbe Extract;Yohimbe Bark Extract.
CAS No.: 65-19-0
English name: Yohimbine;17alpha-Hydroxy-yohimban-16alpha-carboxylic acid methyl ester
Molecular Formula: C21H27ClN2O3
Molecular Weight: 354.49
Active ingredients: Yohimbine hydrochloride
Specification:2%-98% by HPLC
Use Part : Bark Appearance: Brown or White fine powder
Mesh size: Pass 80 Mesh
- Product Description
Yohimbe Standardized Extract – Premium Quality from Bark to Bottle
Yohimbe standardized extract is a potent botanical component for reliability. This African plant, derived from the inner bark of Pausinystalia yohimbe, is now known worldwide for its new active ingredient, yohimbine. Shaanxi Rebecca Biotechnology Co.,Ltd is specialised in creating high-purity product with yohimbine concentration from 2% to 98% by HPLC. With our cutting edge extraction technology and stringent quality control you can be assured of a consistent, pure product every time. Our requirements are customisable to your formulation demands whether you require yohimbine hydrochloride or free alkaloid form.
Technical Specifications
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Parameter |
Details |
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Product Name |
Yohimbe Standardized Extract |
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Other Names |
Yohimbine HCL, Corynante Yohimbe Extract, Yohimbe Bark Extract |
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CAS No. |
65-19-0 |
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Molecular Formula |
C21H27ClN2O3 |
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Molecular Weight |
354.49 |
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Active Ingredient |
Yohimbine Hydrochloride |
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Specification |
2%-98% by HPLC |
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Part Used |
Inner Bark |
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Appearance |
Brown or White Fine Powder |
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Mesh Size |
Pass 80 Mesh |
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Test Method |
HPLC |
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Solubility |
Hydrochloride: Easily soluble in water, ethanol; Free base: Soluble in ethanol, chloroform, slightly soluble in water |
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pH Stability |
Free alkaloids: pH 5.0–7.5; Hydrochloride: pH 3.5–7.0 |
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Storage |
Sealed, light-proof, cool and dry place |
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Shelf Life |
24 months unopened |
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| Test Item | Standard Requirement | Test Result | Judgment |
|---|---|---|---|
| Appearance | Light brown to reddish-brown fine powder, no visible foreign impurities | Reddish-brown fine powder, uniform & clean | Complies |
| Odor & Taste | Characteristic faint bark odor, bitter taste | Conforms to typical sensory properties | Complies |
| Identification (TLC & HPLC) | Chromatogram consistent with Yohimbe bark reference standard & yohimbine reference substance | Positive identification | Complies |
| Yohimbine Content (HPLC) | ≥8.0% | 8.47% | Complies |
| Loss on Drying | ≤5.0% | 2.93% | Complies |
| Total Ash | ≤8.0% | 4.36% | Complies |
| Acid Insoluble Ash | ≤2.0% | 0.82% | Complies |
| Particle Size | 100 mesh pass rate ≥98% | 99.6% | Complies |
| Solubility | Partially soluble in water, soluble in ethanol and dilute acidic solution | Conforms | Complies |
| Lead (Pb) | ≤2.0 ppm | 0.44 ppm | Complies |
| Arsenic (As) | ≤2.0 ppm | 0.25 ppm | Complies |
| Cadmium (Cd) | ≤0.3 ppm | Not Detected | Complies |
| Mercury (Hg) | ≤0.1 ppm | Not Detected | Complies |
| Pesticide Residues | Comply with food safety maximum residue limits | Complies | Complies |
| Total Aerobic Microbial Count | ≤1000 CFU/g | 57 CFU/g | Complies |
| Yeast & Mold Count | ≤100 CFU/g | Not Detected | Complies |
| Escherichia coli | Negative per gram | Negative | Complies |
| Salmonella spp. | Negative per 25g | Negative | Complies |
| Staphylococcus aureus | Negative per gram | Negative | Complies |
Why Choose Us?
Shaanxi Rebecca Biotechnology Co., Ltd. offers you not only the product but also the trust and knowledge.
Advanced R&D Team: Our botanics and chemists are constantly optimising the extraction techniques to retain maximum active ingredients and minimise contaminants.
State-of-the-Art Manufacturing Plant: We adopt high-temperature drying and ultra-fine grinding technology. Our macroporous resin and cation exchange tandem purification system is an industry barrier technology for enhanced batch consistency.
Full Testing Equipments: All batches are checked by HPLC, heavy metal, pesticide residues, microbial test before shipment.
Certifications You Can Trust: We have ISO9001, ISO22000, FSSC22000, HACCP, HALAL, KOSHER, cGMP, and NOP certifications. All items comply with EU EC396 and EU 2023/915.
Global Supply Capacity: Our effective logistics network spans the marketplaces of the world. We offer OEM/ODM customisation and flexible dosage forms like as powder, pills, hard capsules and soft capsules.

Source & Traceability
Quality starts at the source. We source our Pausinystalia yohimbe bark from certified sources.
Raw Material Selection: The inner bark (phloem) is the only part with high quantities of Yohimbine. We also physically peel off the outer bark and xylem prior to extraction, significantly improving production and reducing cost.
Supply Chain Transparency: Every lot is tracked from harvest to final packing. We grade wild bark on its natural alkaloid content before processing it.
Quality Grading: Different specifications serve different markets—from 2%-10% for herbal blends to 95%-98% pharmaceutical-grade extracts.

Solubility & Stability Characteristics
Understanding how your ingredient behaves ensures formulation success.
Solubility Profile:
· Free yohimbine: Almost insoluble in cold water, readily soluble in ethanol, methanol, and chloroform
· Yohimbine hydrochloride: Easily soluble in both cold and hot water, with solubility increased more than 10-fold
· Cyclodextrin modified version: Rapidly disperses in water with no precipitation during storage
Thermal Stability: The process temperature should not exceed 60℃. Alkaloids are degraded at temperatures above 75℃.
pH Stability: The free alkaloids are stable in the pH range 5.0–7.5. The hydrochloride version is stable in the pH range of 3.5–7.0.
Light Sensitivity: Indole ring is rapidly oxidised when exposed to light. We work in dark and pack in light proof materials.
Moisture Control: The higher purity grades are more hygroscopical. Products are packed in moisture proof barrels in vacuum aluminium foil bags

Production Process
Our purifying process is what separates us from the rest.
- Raw Material Pretreatment: Manual sorting of inner bark, removal of outer peel, mould and contaminants. Active chemicals are retained by drying at low temperature of 40–45℃.
- Ethanol-Aqueous Extraction: Materials are refluxed 2-3 times in alkaline ethanol-water solution in sealed containers. This allows the salt production and the entire alkaloids dissolution.
- Low Temperature Concentration: Under vacuum at a temperature of ≤60℃, we concentrate the filtrate and recover ethanol for reuse. Processing in the dark avoids deterioration.
- Tandem Purification System : This is our key competitive edge. First, polysaccharides, pigments and salts are removed with macroporous resin. Then ethanol gradient elution enhance yohimbine. Finally, cation exchange resin removes pseudo-yohimbine and hazardous isomers, to achieve accurate content control within ±1% batch tolerance.
- Decolorisation: Oxidised impurities are removed by treatment with low temperature activated carbon and alkaloid integrity is maintained
- Crystallisation Routes: Solvent gradient recrystallisation for free yohimbine. Hydrochloride: We add dilute hydrochloric acid carefully, to make salt crystals. 95%-98% purity after several recrystallisations.
- Vacuum drying dark , oxygen-free drying ≤60℃ to obtain the final powder.
- Optional Modification: Spray drying with cyclodextrin inclusion technology to improve water solubility.
- Final Processing: Grinding to 80-200 mesh, three-dimensional homogenisation to ensure colour and content homogeneity, and full batch testing before packaging.

Applications & Benefits
Yohimbe standardized extract supports various health applications:
· Promotes healthy blood flow and peripheral circulation
· Supports male vitality and energy levels
· May assist in body composition management through lipolysis promotion
· Helps regulate sympathetic nervous system function
· Used in dietary supplements, functional beverages, and nutraceutical formulations
The hydrochloride shape gives superior bioavailability, making it ideal for professional nutritional supplements requiring higher efficiency.

Quality Assurance
Your confidence counts. So that’s why we have stringent quality systems in place.
Certification Framework: Our facility is certified as ISO9001, ISO22000, FSSC22000, HACCP and cGMP.
In-House Testing: HPLC for yohimbine content and impurity profiles. Each COA will show the data for each impurity, not the total.
Third Party Testing: Heavy metals, pesticide residues, solvents and microbial contaminants tested by independent labs.
Batch Traceability: Full traceability is achieved through complete documentation from the receipt of raw materials to the final shipment.

Packaging & Delivery
Standard Package: inner vacuum-sealed aluminium foil bag, outside moisture-proof cardboard drum. Available in 1kg, 5kg, 10kg and 25kg pack sizes.
Custom Options: We can support private label, unique packaging sizes, blended formulas.
Shipping Way: Samples and small quantity by air freight, bulk quantity by sea freight. On extended ocean journeys, our logistics team guarantees that products reach securely, without any yellowing or agglomeration.

FAQ
Q: Can hazardous alkaloids such as pseudoyohimbine be kept within stringent limits?
A: For sure. Purified using our cation exchange resin purification, specifically removing hazardous isomers. Individual impurity data is provided on the batch COA.
Q: How do you maintain consistent yohimbine content in the face of natural variance in raw materials?
A: We grade wild bark by alkaloid content prior to processing and we employ segmented resin calibration. Batch tolerance is within ±1%.
Q: What's the difference between free base and yohimbine HCl for formulations?
A: Free base is good for herbal complex formulations. Yohimbine HCl offers 10x solubility, more stability and absorption – great for large dose supplements.
Q: Will powder degrade during hot shipping conditions?
A: Low temperature drying and vacuum packaging minimise yellowing, aggregation and loss of content during long transport.
Q: Do you provide samples for testing?
A: Yes we can provide free samples. Order yours today at information@sxrebecca.com
Contact Us
Ready to source premium botanical yohimbe standardized extracts? Reach out to information@sxrebecca.com for technical specifications, pricing, or customization options.
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