Chemical Name:2-mercaptohistidine trimethylbetaine, EGT
CAS No.:497-30-3
Molecular Formula: C9H15 N3O2S
Specification: 99%
Appearance: White Crystalline Powder
Test Method: HPLC
- Product Description
Wholesale L-Ergothioneine Powder: Premium Cellular Antioxidant for Global B2B Supply
Wholesale L-Ergothioneine Powder is a revolutionary development in cell protection technologies in the nutraceutical and cosmeceutical industries. This sulfur-containing amino acid derivative is a master antioxidant with unique bioavailability benefits over traditional options. Unlike other antioxidants that have difficulty penetrating cells, this chemical uses the OCTN1 transporter system to deliver itself to high-stress regions. Shaanxi Rebecca Biotechnology’s product is manufactured via sophisticated fermentation biosynthesis, ensuring the pharmaceutical grade purity. The crystal structure provides excellent stability in various formulation media. This material always satisfies the requirements of modern producers for ingredients which retain biological activity under processing conditions.
Technical Specifications
|
Parameter |
Specification |
||
|
English Name |
L-Ergothioneine |
||
|
CAS Number |
497-30-3 |
||
|
Molecular Formula |
C9H15N3O2S |
||
|
Molecular Weight |
229.3 g/mol |
||
|
Active Content |
≥99.0% (HPLC) |
||
|
Appearance |
White Crystalline Powder |
||
|
Test Method |
HPLC |
||
|
Specific Rotation |
[α]D20: +122° to +128° |
||
|
Solubility |
>100 mg/mL in water (25°C) |
||
|
pH Stability Range |
2.0–9.0 |
||
|
Storage Conditions |
Sealed, dry, room temperature |
||
|
Shelf Life |
24 months |
||
| Test Item | Specification | Result | Test Method |
|---|---|---|---|
| Assay (HPLC) | ≥99.0% | 99.45% | HPLC |
| Loss on Drying | ≤0.5% | 0.21% | Vacuum drying |
| Residue on Ignition | ≤0.1% | 0.05% | Gravimetric |
| Heavy Metals (Pb) | ≤10 ppm | <2 ppm | ICP‑MS |
| Arsenic (As) | ≤2 ppm | <0.5 ppm | ICP‑MS |
| Cadmium (Cd) | ≤1 ppm | <0.1 ppm | ICP‑MS |
| Mercury (Hg) | ≤0.1 ppm | <0.05 ppm | ICP‑MS |
| Total Aerobic Microbial Count | ≤1000 CFU/g | <10 CFU/g | USP <61> |
| Yeast & Mould | ≤100 CFU/g | <10 CFU/g | USP <61> |
| E. coli | Negative /10 g | Negative | USP <62> |
| Salmonella | Negative /10 g | Negative | USP <62> |
Why Choose Us?
Shaanxi Rebecca Biotechnology Co., Ltd. is a vertical integrated manufacturer of plant extracts and bioactive chemicals. We mix the latest fermentation technology with strict quality systems.
Manufacturing Excellence: We utilize food-grade microbial strain fermentation to imitate natural biosynthetic routes. This biological process on the water phase removes the need for chemical reagents. Temperature-controlled fermentation chambers maintain exact pH and oxygen levels over production cycles.
Quality Assurance Infrastructure: All batches are subject to complete testing procedures. Our laboratory offers ICP-MS heavy metal screening, 190+ pesticide residue analysis according to EU EC 396/2005 criteria and complete microbial contamination testing. Purity standards verified by third-party before shipped.
Global Supply Capability: We have a logistics network that allows us to manage the supply chain efficiently for global distribution. We hold a large stock of several categories of purity for urgent purchase requirements. Customization services are available to meet particular particle size requests and formulation requirements.
Certifications Portfolio: ISO9001, ISO22000, FSSC22000, HACCP, HALAL, KOSHER, cGMP, Non-GMO verification and organic certifications provide conformity with worldwide markets.

Production Process
Our Wholesale L-Ergothioneine Powder is performed in eleven stages of precision-controlled:
Stage 1 - Strain Preparation: High-activity edible mushroom fermentation strains are inoculated and activated under sterile conditions. This removes the chance of contamination and ensures the best possible metabolic function.
Stage 2 - Medium Formulation: Natural substrates of food grade are sterilised at high temperature. The absence of competing microorganisms under aseptic conditions favours the growth of a pure strain.
Stage 3 - Biosynthesis Fermentation: Closed liquid fermentation systems maintain constant temperature and oxygen levels. The technique replicates natural fungal metabolism to yield only pure L-isomer molecules.
Stage 4 - Broth Processing: After fermentation, the broth is sterilised and undergoes multi-step precision filtering to effectively remove cell debris and solid residues.
Stage 5 - Membrane Purification: Ultrafiltration technology is employed to remove remaining proteins, polysaccharides and macromolecular impurities from the crude extract solution.
Stage 6 - Ion Exchange Treatment: This is a very advanced desalting process. It removes inorganic salts and ionic contaminants and greatly enhances the whiteness and purity of the finished powder.
Stage 7 - Vacuum Concentration: Low temperature vacuum systems can lower the water content without thermal loss of bioactive components.
Stage 8 - Recrystallization Refining: Controlled recrystallization with a gradient temperature isolates trace impurities without compromising crystal integrity.
Stage 9 - Vacuum Drying: Low-temperature drying produces uniform crystalline powder with stable physicochemical properties and minimal residual moisture.
Stage 10 - Homogenization: Three-dimensional mixing combined with precision sieving removes lot-to-lot variability. The packaging is double layer moisture-proof and light-resistant to avoid degradation during storage.
Stage 11 - Quality Verification: Full analytical testing comprising assay for purity, impurity profile, heavy metals, solvent residues, microbiological limits. Complete documentation meets regulatory traceability criteria.

Applications and Formulation Benefits
Cosmetic Integration: Outstanding stability for your anti-aging serums, blue light protection formulae and sensitive skin repair treatments. The molecule is active throughout high temperature processing and retains activity over pH ranges at which conventional antioxidants are degraded.
Nutraceutical Formulations: Cellular lifespan capsules, mitochondrial support tablets and antioxidant compound powders for better bioavailability benefits. The OCTN1 transport mechanism allows efficient delivery of active substances to target tissues.
Dosage Form Versatility: Compatible with powders, tablets, hard capsules, soft gels and liquid formulations. Without emulsification agents water solubility is >100 mg/mL . This makes formulation development much easier.
Processing Benefits: Heat stable up to 121°C, conforms to established sterilisation methods. Light resistance for storage and presentation to prevent yellowing. Low hygroscopicity means you don’t have to do as much to package it for foreign shipping.

Packaging & Delivery
We provide comprehensive packaging solutions tailored to B2B requirements:
Standard Packaging Options:
· 1kg aluminum foil bags with heat-sealed closures
· 5kg aluminum foil bags with inner polyethylene liners
· 25kg fiber drums with double polyethylene bag inserts
· Custom packaging configurations available upon request
Specialised Protective Measures: Vacuum nitrogen-filled packing avoids oxidative deterioration during long transport times. Two layers of aluminium foil serve as barriers to moisture and light. Desiccant packets in airtight containers help keep humidity at ideal levels.
Shipping Methods: Air freight for urgent orders delivers to major international airports within 5-7 days. Large volumes can be shipped economically by ocean freight with a transit duration of 25-35 days. Sample requests and small volume purchases are handled by express courier services.
Documentation Support: This is a Each shipment will be accompanied by a Certificate of Analysis, Material Safety Data Sheet, commercial invoice, packing list and phytosanitary certificates as applicable. For shipments that are sensitive to climate, temperature monitoring devices can be incorporated.
Global Logistics Coverage: We cooperate with foreign freight forwarders to help make sure customs clearance goes smoothly. Our logistics team manages tracking of door-to-door delivery and documentation requirements in diverse regulatory settings.

FAQ
Q: Can you provide accelerated stability data for long-distance shipping conditions?
A: Yes, 3-month accelerated stability testing under 40℃/75%RH conditions is available upon request. Our vacuum nitrogen-filled packaging effectively prevents moisture absorption and oxidation during extended transportation.
Q: What testing protocols ensure raw material purity?
A: Every batch completes ICP-MS heavy metal analysis, 190+ EU standard pesticide residue screening, and comprehensive microbial testing. All results appear on the Certificate of Analysis with full specification compliance.
Q: Do you offer customized specifications?
A: Multiple grades available including 98%, 99.0%, and 99.5% purity levels. Particle sizes from 80-100 mesh to 200 mesh ultra-fine powder accommodate various formulation requirements for both oral and topical applications.
Contact Us
For procurement inquiries or technical specifications regarding Wholesale L-Ergothioneine Powder, contact our export team at information@sxrebecca.com.
_1730691017423.webp)













