【Another Name】: Vanillyl-N-nonylamide,Pelargonic Acid-Vanillylamide,Synthetic Capsaicin.
【CAS 】: 2444-46-4
【Active Ingredients】: Nonivamide
【Specification】: Nonivamide Min 70%
Nonivamide Min 98%
Nonivamide Min 98% 【Appearance】: Off-white to white Powder
【Test Method】: HPLC
【Molecular Formula】: C17H27NO3
【Molecular Weight】: 293.4
【Solubility】: Soluble in Chloroform, Ethanol & Insoluble in Water.
- Product Description
High-Purity Nonivamide Powder: Synthetic Capsaicinoid for Topical Analgesic & Functional Formulations
Industrially grade nonivamide is a capsaicinoid analogue that has been scientifically synthesised to overcome the natural variability, batch to batch inconsistency and agricultural impurity problems associated with extracting capsaicin from natural sources. Nonivamide Powder is manufactured by controlled chemical synthesis of vanillylamine and pelargonic acid to generate a standardised TRPV1 receptor agonist with greater thermal stability and reproducible pharmacological response. This off-white to white crystalline compound solves key B2B pain points including precise dosing requirements in topical analgesic formulations, regulatory compliance in cosmetic applications and elimination of natural pepper allergens, enabling manufacturers to deliver consistent sensory heat and therapeutic efficacy across diverse topical delivery systems.
Nonivamide Powder Specifications
|
Parameter |
Value |
|
|
CAS Number |
2444-46-4 |
|
|
Molecular Formula |
C17H27NO3 |
|
|
Molecular Weight |
293.4 g/mol |
|
|
Appearance |
Off-white to white powder |
|
|
Purity Grades |
70% Min / 98% Min |
|
|
Test Method |
HPLC |
|
|
Melting Range |
55–61°C |
|
|
Solubility |
Soluble in ethanol, chloroform; insoluble in water |
|
|
Heavy Metals |
≤10 ppm |
|
|
Shelf Life |
24 months (sealed, dark, dry storage) |
|
| Item | Specification | Result |
|---|---|---|
| Nonivamide Assay | ≥98.0% | 98.62% |
| Melting Point | 54‑58℃ | 55.2‑56.7℃ |
| Loss on Drying | ≤0.50% | 0.21% |
| Residue on Ignition | ≤0.10% | 0.05% |
| Particle Size | 80 mesh pass ≥95% | 98.2% pass 80 mesh |
| Solubility | Soluble in ethanol, insoluble in water | Complies |
| Item | Specification(ppm) | Result(ppm) |
| Lead (Pb) | ≤2.0 | 0.32 |
| Arsenic (As) | ≤2.0 | 0.18 |
| Cadmium (Cd) | ≤1.0 | 0.07 |
| Mercury (Hg) | ≤0.1 | <0.01 |
| Item | Specification(ppm) | Result(ppm) |
| Lead (Pb) | ≤2.0 | 0.32 |
| Arsenic (As) | ≤2.0 | 0.18 |
| Cadmium (Cd) | ≤1.0 | 0.07 |
| Mercury (Hg) | ≤0.1 | <0.01 |
Why Choose Us
Shaanxi Rebecca Biotechnology Co., Ltd. merges R&D, manufacturing and worldwide supply chain management.
Our closed-loop synthesis facility employs advanced catalysed amidation reactors and multi-stage recrystallisation purification for batch-to-batch purity consistency.
We are ISO9001, ISO22000, FSSC22000, HACCP, HALAL and KOSHER certified with third party verification for heavy metals and residual solvents.
Our technical team offers OEM/ODM customisation on powder, capsule, tablet and liquid-ready formulations.
Fast and safe delivery of Nonivamide Powder to customers worldwide is guaranteed thanks to our scalable production capacity and logistical networks according to the norms of EU EC396 and EU 2023/915.

COA

HPLC Chromatogram



SGS Test Report of Nonivamide
SGS Lab, conducted a Full Analysis of Nonivamide (Synthetic Capsaicin),And Test Report says: All Test Results are conforming with Both Chinese Pharmacopoeia and Japanese Pharmacopoeia.
So,Our Nonivamide (Synthetic Capsaicin), is totally Qualified to be used in External-use Pharmaceutical Products.



Differences in the effects of synthetic capsaicin and natural capsaicin
Nonylic Acid Vanillylamide is a higher purity capsaicin with a stronger spicy taste and a longer-lasting anti-inflammatory and analgesic effect. At the same time, synthetic capsaicin has also been proven to have multiple functions such as anti-cancer and weight loss. Synthetic capsaicin is also widely used in the fields of capsaicin paint, rodent and insect repellent additives, etc.
Natural capsaicin(CAS 2444-46-4) is mainly made of peppers and is obtained through extraction, purification and other processes. In addition to its anti-inflammatory and analgesic effects, it can also promote gastric juice secretion, increase appetite, improve digestive function, promote blood circulation, lower cholesterol, control blood pressure, and prevent thrombosis. In addition, natural capsaicin is widely used in the fields of food and medicine, and its product added value is high.
In general, although both synthetic capsaicin and natural capsaicin have anti-inflammatory and analgesic effects, there are differences in their efficacy and uses in specific applications.

Source & Traceability
All batches start with pharmaceutical-grade vanillylamine and pelargonic acid provided by qualified chemical suppliers providing full traceability documentation.
Our wholly synthesised method avoids agricultural pesticide residues, capsanthin pigments, and varied capsaicinoid homologs seen in natural capsaicin.
Raw materials are checked thoroughly for heavy metals and harmful impurities before production.
All synthesis is performed in closed reaction environments in our facility to avoid cross-contamination, providing a clean, reproducible synthesis pathway without the variability of plant origin.

Solubility & Stability Characteristics
Nonivamide Powder dissolves rapidly in ethanol, isopropyl alcohol, propylene glycol and cosmetic oil bases, making it perfect for ointments, liniments and massage creams.
It is very poorly soluble in cold water, so water-based systems require co-solvents or solubilizers.
The compound is stable below 65°C, but amide bond degradation can occur above that temperature.
It is sensitive to UV radiation and must be packaged in light-proof containers.
Best stability is pH 5-7.
The amide bond is degraded in extreme alkaline circumstances.
Stability is maintained for 24 months when stored sealed and protected from light and moisture.

Production Process
The synthesis begins with accurately weighed amounts of pelargonic acid and vanillylamine in a dust-free environment.
Catalysed amidation is carried out in closed reactors with well-controlled temperature conditions to minimise adverse reactions.
The crude product is washed with primary solvent to remove catalysts and unreacted precursors and then subjected to multi-stage gradient recrystallisation to remove homologous impurities.
Low temperature vacuum drying followed by ultrafine milling to 80 to 200 mesh depending on the application maintains chemical integrity.
3D homogenisation guarantees the uniformity of the batch.
Final goods are vacuum packed in nitrogen flushed aluminium foil bags in fibre drums and sent for HPLC testing for purity, residual solvent analysis, heavy metal screening and microbiological inspection prior to archiving and release.

Applications & Functions
Pharmaceutical: Used in pain treatment ointments, joint gels, muscle balms, warming plasters and sports recovery lotions to provide localised analgesia and improve circulation.
Cosmetic & Personal Care :Vasodilation and stimulation of follicles make them useful in anti-hair loss scalp serums, slimming massage lotions, body warming creams and facial treatments for pore refining.
Daily Chemical & Agricultural :Used in Green insect repellents, animal repellents, anti-fouling coatings and low toxicity Botanical Pesticide Synergists.

Quality Assurance
We are certified in ISO9001, HALAL, KOSHER, cGMP, HACCP and Non-GMO for our quality system.
Each batch undergoes HPLC quantitative analysis, heavy metal testing (ICP-MS), residual solvent screening (GC-FID) and microbiological profiling.
Third-party laboratories validate purity and safety with full traceability from raw material to finished product.
Complete batch records and Certificates of Analysis available upon request.

Packaging & Delivery
Standard packaging is 25 kg plastic lined fibre drums with vacuum nitrogen filled aluminium foil inner bags for superior protection from light and moisture.
Custom options including smaller retail packs (1kg, 5kg) and private label.
We provide flexible deliveries by air, sea and fast courier with temperature-controlled logistics to ensure the integrity of the products.
Documentation includes MSDS, COA and export compliance certifications.
We have an extensive worldwide distribution network that guarantees prompt delivery and complete tracking of your item.

FAQ
Q: Is this fully synthetic or extracted from peppers?
A: It is 100% chemically synthesized, eliminating natural pepper variability and allergens. Synthesis route documents are available.
Q: Can you supply 95% and 98% purity stably?
A: Yes, 70% and 98% are standard; custom purities can be arranged per client specifications.
Q: What packaging prevents degradation? What is shelf life?
A: Vacuum nitrogen-filled aluminum foil bags in sealed fiber drums. Shelf life is 24 months; use promptly after opening.
Q: What dosage forms and restrictions apply?
A: Suitable for ointments, creams, plasters, scalp essences, lotions. External use only; avoid >65°C processing and strong alkaline pH.
Q: Is batch testing documentation provided?
A: Yes, COA, HPLC chromatograms, heavy metal reports, and third-party validation are supplied with every shipment.
Contact us
For Nonivamide Powder specifications, customized formulations, or bulk inquiries, contact us at information@sxrebecca.com. Shaanxi Rebecca Biotechnology delivers reliable, high-purity ingredients that empower your formulations with consistency and efficacy.
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