Baicalein Powder

• We have cleanrooms to 100,000 class and operate to pharmaceutical-grade manufacturing requirements.
• Processing is carried out with advanced high temperature drying and ultra fine grinding methods to protect active chemicals.
• We have total traceability from raw material procurement through to final packaging assuring compliance to EU EC396 and EU 2023/915 regulations.
• Our R&D team is specialised in flavonoid extraction & purification.
• Each batch is tested using state-of-the-art equipment for heavy metals, pesticide residues and microbiological composition.
• International Certifications: ISO9001, ISO22000, HACCP, HALAL and KOSHER.
• We offer versatile OEM/ODM services with unique dosage forms for powder, tablet, capsule and liquid formulations.

We choose mature roots of Scutellaria baicalensis of as least 3 years of age. The raw material is sorted very carefully to remove any parts that are hollow, mouldy or bug damaged. Three distinct grades serve different applications:

Conventional Extraction Grade is for 95% goods with routine quality control. High-Purity Refined Grade consists of pre-screened roots from genuine growing places, and is only for 98-99% requirements. Export Traceability Grade is fully documented from planting through processing and is manufactured on dedicated lines to avoid cross-contamination.

Quality screening starts at harvest. The roots are air-dried and kept in the dark to prevent the destruction of flavonoids. This methodical methodology provides consistent chemical profiles across production batches.

Baicalein is not readily soluble in water but is soluble in ethanol, methanol and acetone. For aqueous formulations we provide cyclodextrin-modified formulations which disperse swiftly in cold water without precipitation.

Thermal Stability: Recommended processing temperatures are below 65°C. Extended exposure beyond 80 °C leads to oxidation and activity loss.
pH Range: Optimal stability is from pH 4.0-7.2. Strong acids promote isomerisation .Alkaline environments promote degradation .
Light Sensitivity: The dry powder is stable in sealed, light-proof packaging for 24 months.
UV protection is required for aqueous solutions to prevent oxidative yellowing.

Our production starts with raw material pre-treatment, where roots are cleaned, sliced and dried under controlled temperature before grinding to 20-30 mesh. Baicalin glycosides were extracted by ethanol reflux extraction and then concentrated at low temperature under vacuum to retain thermolabile chemicals.

The main conversion is a controlled acid hydrolysis that breaks the glycosidic linkages and converts baicalin to free baicalein. The solution is cooled crystallisation after neutralisation of pH. Gradient elution of macroporous resin adsorption to remove polysaccharides and pigments.

Recrystallisation is used to obtain the final purity: single-stage recrystallisation results in 95% purity, dual-stage recrystallisation in 98% purity, and numerous deep recrystallisations combined with preparative chromatography in 99% purity. The crystals are cleaned, centrifuged and vacuum dried below 65 °C to prevent oxidation. The final procedures involve grinding, sieving to the required mesh sizes and 3-dimensional mixing to achieve batch uniformity.

Baicalein anti-acne serums and brightening creams: tyrosinase activity and inflammatory mediators (IL-1β, TNF-α) are suppressed by baicalein. It improves photoprotection in mineral sunscreen systems.

Nutraceuticals: Used in hepatoprotective supplements and immune modulators The chemical is stable in stomach circumstances and has good bioavailability when absorbed from the intestine. Pharmaceutical development: Used as a high purity intermediate for the research of anti-inflammatory and neuroprotective medicines.

Each batch of Baicalein Powder is tested extensively for content, heavy metals, pesticide residues and microbial contamination. Results are validated by third party laboratories against worldwide pharmacopoeial standards. Our quality management system is ISO9001, FSSC22000 and cGMP certified.

Traceability of raw materials goes down to individual harvest lots. The testing equipment consists of HPLC, GC-MS, ICP-MS and microbiological analysis systems. Each shipment is accompanied by a Certificate of Analysis for all important quality parameters.

Standard Packing: Double PE bags (net 5 kg) in moisture-proof paper drums (net 25 kg). Special packaging available for special volume requirements or branding demands.

Shipping Methods: Samples are sent by express courier, rush orders by air freight and bulk by sea freight. Temperature-controlled logistics help maintain product integrity throughout transportation. All shipments are fully documented for customs clearance.

Q: What is your source of raw material?

A: We extract from verified Scutellaria baicalensis roots, with full traceability documentation.

Q: What are the differences between purity grades?

A: 95% is cost effective for common purposes 98% is suitable for most cosmetic and supplement applications 99% is research grade pure for pharmaceutical development

Q: How long will it last?

A: Vacuum sealed packaging when stored appropriately, away from light, heat and moisture, is stable for 24 months.

Q: Can you make water soluble forms?

A: Yes, inclusion complexes with cyclodextrins allow for aqueous dispersion for liquid formulations.

Q: Do you provide customisation services?

A: OEM/ODM We offer a range of services from bespoke specs, packaging and multiple dosage forms.

Partner with Shaanxi Rebecca Biotechnology for reliable Baicalein Powder supply backed by technical expertise and quality assurance. contact us at information@sxrebecca.com to discuss your specific formulation requirements.​​​​​​​