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5 Aminolevulinic Acid Hcl
CAS No.: 5451-09-2
Molecular Formula: C5H10ClNO3
Active ingredients:5-Aminolevulinic Acid HCL（5-ALA)
Specification: 98%
Appearance: White to light yellow powder
Test Method: HPLC
- Product Description
5 Aminolevulinic Acid HCl Product Introduction
ABOUT 5 Aminolevulinic Acid HCl
5 Aminolevulinic Acid HCl (5-ALA HCl) is a highly sought-after compound used primarily in the development of drugs and therapies in the fields of oncology, dermatology, and diagnostics. The compound has proven efficacy in photodynamic therapy (PDT) for cancer treatment, particularly in the targeting of tumors.
At Shaanxi Rebecca Bio-Tech, we use advanced technologies like high-temperature drying and ultra-fine grinding to preserve the nutrients and natural flavors, ensuring the highest purity in every batch of HCl we supply. Our dedication to quality means our product is highly pure, stable, and suitable for a variety of pharmaceutical applications.
5-Aminolevulinic acid hydrochloride, also known as 5-Aminolevulinic acid hydrochloride, is a white or light yellow solid powder at room temperature and pressure. It is soluble in water and common protic solvents, but has poor solubility in ether organic solvents.
The properties of 5-aminolevulinic acid hydrochloride are mainly nitroacetic acid ester and succinic anhydride, which are easily available on the market and are moderately priced. Under strong alkaline conditions, nitroacetic acid ester reacts with succinic anhydride in an organic solvent to produce 5-ester-5-nitro-4-oxo-pentanoic acid. This step is the key in the synthesis process, and the reaction conditions and raw material ratios need to be precisely controlled to ensure the purity and yield of the product. The 5-ester-5-nitro-4-oxo-pentanoic acid obtained in the previous step is reduced in a solvent by a reducing agent (such as iron powder, zinc powder, etc.) to obtain 5-ester-5-amino-4-oxo-pentanoic acid. The selectivity of the reduction reaction is crucial for subsequent steps, and other unnecessary side reactions need to be avoided. 5-Ester-5-amino-4-oxo-pentanoic acid is hydrolyzed under acidic conditions to generate 5-aminolevulinic acid. Subsequently, it is converted into a hydrochloride form, i.e., 5-aminolevulinic acid hydrochloride, by adding hydrochloric acid. The product is purified by recrystallization and other methods to obtain high-purity 5-aminolevulinic acid hydrochloride. Finally, it is dried under dry conditions to remove residual moisture and solvent.
Specifications
| Parameter | Specification |
|---|---|
| Product Name | 5 Aminolevulinic Acid HCl |
| Chemical Formula | C5H9NO3·HCl |
| Molecular Weight | 165.59 g/mol |
| Purity | ≥98% |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in water |
| Melting Point | 150-160°C |
| Storage Conditions | Store in a cool, dry place, away from sunlight |
| Shelf Life | 2 years under recommended storage conditions |
Application Areas
It is a versatile compound with various applications across multiple industries:
Pharmaceutical field: 5-aminolevulinic acid hydrochloride is mainly used in the preparation of some calcium channel blockers (such as Huishenmiao and Nitrendipine) and cardiovascular system drugs in the pharmaceutical field. As a raw material for calcium channel blockers, 5-aminolevulinic acid hydrochloride can dilate blood vessels, lower blood pressure, prevent angina pectoris, coronary heart disease, etc. by preventing calcium ions from entering myocardial and smooth muscle cells. In addition, 5-aminolevulinic acid also has a certain anti-platelet aggregation effect and can be used to prevent thrombosis.
Organic synthetic chemistry: It can be used as a structural modification and synthetic intermediate for a variety of organic molecules and bioactive molecules. For example, in the research and development of anti-tumor drugs, 5-aminolevulinic acid hydrochloride is often used as a synthetic precursor or intermediate to optimize the biological activity and pharmacokinetic properties of drugs by introducing specific functional groups or structural units.
Biochemical research: It is mainly used as a substrate for 5-aminolevulinic acid dehydrogenase and can be used for biochemical research.
Agriculture: It is a synthetic precursor of tetrapyrrole compounds (such as chlorophyll, vitamin B12, etc.), so it also has important application value in the agriculture field.
Food: It is widely distributed in animals and plants and in food, so it also has certain applications in the food field.
Efficacy of 5-aminolevulinic acid hydrochloride
5 Aminolevulinic Acid HCl performs well in preventing hyperlipidemia, hypertension, and hyperglycemia. It can also promote the absorption and utilization of iron, increase the synthesis of hemoglobin, improve anemia symptoms, promote children's growth, enhance physical strength, improve children's motor ability, regulate nervous system function, relieve tension, and improve brain cognitive function.
5-aminolevulinic acid hydrochloride, referred to as ALA-HCl, is a compound that has received widespread attention in the field of nutrition and health care. It can effectively lower the cholesterol and triglyceride levels in the blood and reduce fat deposition on the blood vessel walls, thereby preventing the occurrence of cardiovascular diseases.
It can promote the secretion and utilization of insulin, help maintain blood sugar stability, and has a certain auxiliary therapeutic effect on diabetic patients. It can promote the absorption and utilization of iron, increase the synthesis of hemoglobin, and thus improve anemia symptoms.
For patients with iron deficiency anemia, appropriate supplementation of ALA-HCl can help quickly restore health. ALA-HCl also plays an important role in promoting children's growth.
It can enhance physical strength, improve children's athletic ability, and make them more energetic in learning and life. It can regulate the function of the nervous system, relieve tension, and make people feel peaceful and relaxed. For problems such as anxiety, proper supplementation of ALA-HCl can help improve the quality of life. It has a positive effect on improving the cognitive function of the brain, which helps improve learning efficiency and work ability.
Production Process
The production of HCl at Shaanxi Rebecca Bio-Tech follows stringent industry protocols to ensure high purity and stability:
- Synthesis: The compound is synthesized using advanced fermentation and chemical methods.
- Purification: Ultra-fine grinding techniques are employed to ensure the compound’s purity while maintaining its natural properties.
- Quality Control: Each batch undergoes rigorous testing for purity, heavy metals, and microbiological contaminants.
Packaging and Transportation
- Packaging: Available in 1 kg, 5 kg, and 25 kg options in sealed, moisture-proof containers.
- Transportation: Shipped in compliance with international standards to ensure the integrity of the product during transit.
After-Sales Service
At Shaanxi Rebecca Bio-Tech, our commitment to customer satisfaction extends beyond the sale.
- Technical Support: Our team of experts is available to assist with any product-related inquiries.
- Product Guidance: We offer tailored advice to ensure that 5 Aminolevulinic Acid HCl is used effectively in your research or production processes.
- Timely Support: Our dedicated customer service team ensures that you receive prompt responses to any queries.
Qualification Certification
- GMP Certification: Ensuring compliance with Good Manufacturing Practices.
- FDA Certification: Adhering to rigorous FDA standards for pharmaceutical production.
- ISO Certification: Demonstrating our commitment to quality and environmental responsibility.
FAQ
Q1: What industries use 5 Aminolevulinic Acid HCl?
- 5 Aminolevulinic Acid HCl is used primarily in the pharmaceutical, biotechnology, and dermatology industries.
Q2: How is the quality of the product ensured?
- We conduct thorough quality control tests at every stage of production and provide a detailed COA for each batch.
Q3: Can I receive a sample of the product before making a purchase?
- Yes, we offer shipping samples to allow for testing and evaluation before placing an order.
Q4: What is the typical lead time for orders?
- Lead times vary depending on order size, but we strive to deliver products within 5-10 business days.
