Latin Name: Silybum marianum.L
CAS No.: 22888-70-6 / 65666-07-1
Molecular forula:C25H22O10
Molecular Weight:482.44
Active ingredients: Silymarin & Silybin
Specification: Silymarin 80% UV, Silybin 30% HPLC
Use Part : seed
Appearance: yellowish fine powder
Mesh size:80 Mesh
Test Method: UV
- Product Description
Premium Milk Thistle Extract Powder – Standardized Silymarin for Liver Health Solutions
The market for botanical extracts is becoming more and more focused on ingredients that protect the liver and are supported by rigorous quality control and clinical proof internationally. Milk Thistle Extract Powder is a standardised phytochemical concentrate with scientific confirmation of reproducible silymarin content derived from Silybum marianum seeds. This bioactive complex supports pathways of hepatocyte regeneration, antioxidant defence and metabolic detoxification. We are a skilled manufacturer of high grade pharmaceuticals. Shaanxi Rebecca Biotech Co. Ltd. To retain the integrity of the flavonolignans and to meet international purity requirements, we use an ethanol extraction procedure.
Milk Thistle Extract Powder Specifications
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Parameter |
Specification |
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Botanical Name |
Silybum marianum L. |
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CAS Number |
22888-70-6 / 65666-07-1 |
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|
Active Components |
Silymarin & Silybin |
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|
Standardization |
Silymarin 80% UV / Silybin 30% HPLC |
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|
Appearance |
Yellowish Fine Powder |
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Particle Size |
80 Mesh (95% pass rate) |
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Moisture Content |
≤ 5.0% |
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Test Method |
UV-Vis / HPLC |
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Solubility |
Ethanol, Methanol, Alkaline Solution |
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|
Shelf Life |
24 Months (sealed, cool, dark storage) |
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| Test Item | Specification | Test Result | Test Method |
|---|---|---|---|
| Physico‑Chemical Test Results | |||
| Appearance | Yellow‑brown fine powder | Yellow‑brown fine powder | Visual |
| Odor | Characteristic herb odor | Complies | Organoleptic |
| Silymarin Content | ≥80.0% | 81.4% | HPLC |
| Loss on Drying | ≤5.00% | 3.21% | USP‑NF |
| Total Ash | ≤7.00% | 4.15% | USP‑NF |
| Water‑Soluble Extract | Complies | Complies | Extraction method |
| Particle Size | 100% pass 80 mesh | 100% pass 80 mesh | Sieve analysis |
| Heavy Metals Safety Test | |||
| Lead (Pb) | ≤2.0 mg/kg | 0.42 mg/kg | ICP‑MS |
| Arsenic (As) | ≤2.0 mg/kg | 0.28 mg/kg | ICP‑MS |
| Cadmium (Cd) | ≤1.0 mg/kg | 0.11 mg/kg | ICP‑MS |
| Mercury (Hg) | ≤0.1 mg/kg | <0.05 mg/kg | ICP‑MS |
| Microbiological Limit Test | |||
| Total Aerobic Count | ≤10⁴ cfu/g | 1.2×10³ cfu/g | USP‑61 |
| Yeast & Mould | ≤10² cfu/g | 35 cfu/g | USP‑61 |
| E. coli | Negative /10g | Negative | USP‑62 |
| Salmonella | Negative /25g | Negative | USP‑62 |
| Staphylococcus aureus | Negative /10g | Negative | USP‑62 |
Why Choose Us
Shaanxi Rebecca Biotechnology Co., Ltd. is an integration of research, production and global distribution, supplying botanical extracts meeting pharmaceutical grade requirements.
In our facilities, we are using high temperature drying technology and ultra-fine grinding technology to keep the most nutrients.
A complete quality management system controls each step of the production process and is certified according to ISO9001, HALAL, KOSHER, cGMP, ISO22000, FSSC22000 and HACCP.
Our R&D team is always working on improving extraction techniques for increased bioavailability while still adhering to EU EC396, EU 2023/915 and solvent residue regulations.
With a robust global logistics network, we are able to deliver on time and provide flexible OEM/ODM services for customised formulations from powder blends to softgels.

Source & Traceability
The raw ingredients are sourced from approved growing areas in Xinjiang, Gansu, Inner Mongolia and selected European sources.
These regions have optimal growing conditions, including dry climate, intense sunlight and low rainfall, which favour high silymarin accumulation and low risk of mycotoxins.
The seeds are mechanically winnowed and hand sorted to remove faulty grains.
Each batch is accompanied by verifiable agricultural records including pesticide use and heavy metal levels, and arriving inspection reports, providing transparency from farm to finished product.

Solubility & Stability Profile
Standard Milk Thistle Extract Powder is insoluble in water but soluble in ethanol and methanol.
For liquid applications, water soluble derivatives are available incorporating cyclodextrin complexes or PEGylation.
The temperature is kept below 55 °C for thermal stability, but oxidation of flavonolignans is faster at higher temperature.
Extract is photosensitive; extended exposure to light will result in loss of colour and efficacy.
The molecular structure is preserved in neutral and slightly acidic environments (pH 6.0–7.5) but is degraded under strong alkaline conditions.
Slightly hygroscopic. Needs moisture-proof packaging for 24-month shelf stability.

Manufacturing Process
The production process includes sifting of raw seeds, cleansing with purified water and drying with low-temperature air.
Low temperature crushing of seed releases silymarin without thermal damage.
The food-grade ethanol gradient reflux extraction is carried out in closed systems at temperatures below 55°C to avoid oxidation.
Multi-stage filtration is carried out using plate-frame coarse filtration and precision membrane systems for removal of fibre and insoluble materials.
Target flavonolignans were enriched via macroporous resin columns, whereas polysaccharides and tannins were removed.
Negative-pressure vacuum concentration is used to recover the ethanol solvent under shaded circumstances to minimise local warming.
Free flowing powder is obtained via aseptic spray drying with regulated input and output temperatures.
For ultrafine grinding, solid solids are ground to 80-100 mesh, liquids to 200 mesh.
Three-dimensional rotary mixing to ensure uniformity of each batch, then vacuum nitrogen packing in aluminium foil inner bags and 25kg fibre drums.

Applications & Efficacy
Dietary Supplements: Liver protection pills, hangover treatment tablets, daily liver conditioning powders, functional drinks aimed at alcohol drinkers, shift workers.
Cosmetics: Body care anti-aging products, facial care anti-inflammatory additives, antioxidant serums, skin barrier repair preparations.
Core Mechanisms: Stabilise hepatocyte membranes from toxin infiltration; promote regeneration of damaged tissue; neutralise free radicals and reduce oxidative stress; enhance bile secretion for fat metabolism; accelerate clearance of hepatic toxins.

Quality Assurance
All production is under ISO9001 and cGMP frameworks. In-house labs with HPLC, UV-Vis spectrometers and heavy metal analysers validate silymarin content, pesticide residues and microbiological limits. Third party testing by certified labs certifies conformity with USP and EP requirements. Batch-to-batch traceability connects completed goods to their source documents for accountability. It is non-GMO, vegan friendly and complies with EU maximum residue regulations.

Packaging & Delivery
The standard packaging is double layer food-grade polyethylene bags with desiccant packs, sealed in 25kg fibre drums to protect against moisture and light.
For smaller orders, aluminium foil bags of 1kg, 5kg or 10kg are available, while industrial clients may choose to buy in bulk totes.
We provide neutral labelling for your OEM partners and branded packaging to your needs.
We can send sample by Fedex or DHL express, or by air freight for urgent bulk orders, and by ocean freight for economical large volume orders.
All shipments are accompanied by certifications of Analysis, MSDS paperwork and phytosanitary certifications where applicable.
Temperature regulated logistics helps to maintain product integrity in transportation.

Frequently Asked Questions
Q: Can you supply origin certificates for raw materials?
A: Yes, we provide official planting certifications and inspection documents from domestic and European sources.
Q: What is the minimum order quantity and lead time?
A: Sample MOQ is 1kg; bulk production requires 7–10 working days after deposit confirmation.
Q: Which dosage forms work best with your extract?
A: Capsules, tablets, and powder blends are ideal. Avoid processes exceeding 60°C or strong alkaline environments.
Q: How do you ensure consistent potency across batches?
A: HPLC testing verifies silymarin content, and three-dimensional blending homogenizes batches before packaging.
Q: Is the extract suitable for vegan formulations?
A: Absolutely. The powder contains no animal-derived ingredients, though capsule shells must be sourced separately.
Contact us
Contact Shaanxi Rebecca Biotechnology Co., Ltd. at information@sxrebecca.com to request samples, discuss custom specifications, or learn how our Milk Thistle Extract Powder can enhance your product portfolio with proven liver-supportive compounds.
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